A Japanese start-up company and a pioneer of the World's First Cell-Free Amplification Technology for Large Circular DNA.
The company is seeking a highly motivated Senior Scientist to setup mammalian cell transfection capabilities. The candidate will play a key role in establishing the aforementioned technologies as well as implementing any appropriate downstream analyses and optimizations of hits/probes coming out of the panning efforts. You will report to and work closely with the Chief Technology Officer. You will also manage other scientists where needed to accelerate development.
Expand the application of DNA technology to gene therapy and cell engineering field.
Compare and determine appropriate vector and transfection technologies.
Design and construction of transfection vectors, and evaluate transfection efficiency in mammalian cells (flowcytometry, fluorescence microscopy, cytotoxicity assay, western-blotting, qPCR, etc.).
Organize and execute multiple projects in a fast-pace and collaborative environment
PhD in biological sciences or a relevant field and biologics drug discovery in biotech/pharmaceutical industry, or M.S. with Industry Experience
Direct hands-on experience in library construction, screening and evaluating various display technologies including phage display (M13, fd, T4, T7, λ, etc.) and yeast display.
Proficiency in a wide variety of binding assays (ELISA, TR-FRET, SPR, flow cytometry, etc.) and the ability to set up custom binding assays where needed.
Bioinformatics capabilities to analyze NGS data from panning efforts.
Ability to work in an independently, highly organized manner and propose creative yet critical troubleshooting solutions.
The ability to rapidly understand and learn new technologies that aid in biological analysis and integrate new technologies into existing projects.